JPS6416724A - Stable and injectable vinca dimer salt solution - Google Patents
Stable and injectable vinca dimer salt solutionInfo
- Publication number
- JPS6416724A JPS6416724A JP63056522A JP5652288A JPS6416724A JP S6416724 A JPS6416724 A JP S6416724A JP 63056522 A JP63056522 A JP 63056522A JP 5652288 A JP5652288 A JP 5652288A JP S6416724 A JPS6416724 A JP S6416724A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- ethylenediaminetetraacetate
- vinca dimer
- aqueous solution
- injectable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000863480 Vinca Species 0.000 title abstract 3
- 239000000539 dimer Substances 0.000 title abstract 3
- 239000012266 salt solution Substances 0.000 title 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000008351 acetate buffer Substances 0.000 abstract 2
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 abstract 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 2
- 229960002216 methylparaben Drugs 0.000 abstract 2
- 238000004321 preservation Methods 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 230000002335 preservative effect Effects 0.000 abstract 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 abstract 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 abstract 2
- 229960003415 propylparaben Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- AYRVGWHSXIMRAB-UHFFFAOYSA-M sodium acetate trihydrate Chemical compound O.O.O.[Na+].CC([O-])=O AYRVGWHSXIMRAB-UHFFFAOYSA-M 0.000 abstract 1
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 abstract 1
- 229960002110 vincristine sulfate Drugs 0.000 abstract 1
- -1 vincristine sulfate) Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL83086A IL83086A (en) | 1987-07-06 | 1987-07-06 | Stable,injectable solutions of vincristine salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6416724A true JPS6416724A (en) | 1989-01-20 |
| JPH0525857B2 JPH0525857B2 (en]) | 1993-04-14 |
Family
ID=11057953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63056522A Granted JPS6416724A (en) | 1987-07-06 | 1988-03-11 | Stable and injectable vinca dimer salt solution |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4883805A (en]) |
| EP (1) | EP0298192B1 (en]) |
| JP (1) | JPS6416724A (en]) |
| AT (1) | ATE65401T1 (en]) |
| CA (1) | CA1303992C (en]) |
| DE (1) | DE3863859D1 (en]) |
| ES (1) | ES2028917T3 (en]) |
| IL (1) | IL83086A (en]) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007515461A (ja) * | 2003-12-23 | 2007-06-14 | ピエール、ファーブル、メディカマン | 非経口投与を目的とするビンフルニンの医薬組成物、その調製方法およびその使用 |
| JP2015127300A (ja) * | 2013-12-27 | 2015-07-09 | 富士フイルム株式会社 | 注射液製剤及びその製造方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU204995B (en) * | 1989-11-07 | 1992-03-30 | Richter Gedeon Vegyeszet | Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| DE19818802A1 (de) * | 1998-04-27 | 1999-10-28 | Dresden Arzneimittel | Stabile Mitoxantron-Lösungen |
| US6849655B2 (en) | 2000-05-15 | 2005-02-01 | Kissei Pharmaceutical Co., Ltd. | Aqueous liquid formulations |
| US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
| WO2004091623A1 (en) | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals. Inc. | Pharmaceutical formulations containing methylnaltrexone |
| EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| US7923037B2 (en) * | 2006-10-05 | 2011-04-12 | Ikaria, Inc. | Liquid chalcogenide compositions and methods of manufacturing and using the same |
| EP3328385B1 (en) * | 2015-08-01 | 2020-07-08 | Sun Pharmaceutical Industries Ltd | Dosage form of vinca alkaloid drug |
| CN114699369A (zh) * | 2022-05-19 | 2022-07-05 | 青岛农业大学 | 一种盐酸溴己新注射液及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248291A (en) * | 1963-08-19 | 1966-04-26 | Hoffmann La Roche | Stabilized thioxanthene derivatives and method of using the same |
| GB1254057A (en) * | 1969-04-24 | 1971-11-17 | Louisette Olivier | Improvements in or relating to therapeutical composition containing vincamine |
| GB2020180B (en) * | 1978-05-08 | 1982-08-25 | Nelson Res & Dev | Ophthalmic compositions containingcolchicine or vinblastinr |
| US4619935A (en) * | 1983-03-17 | 1986-10-28 | Eli Lilly And Company | Stable oncolytic formulations |
| US4708962A (en) * | 1984-12-17 | 1987-11-24 | Harbor Branch Oceanographic Institution, Inc. | Antiviral and antitumor cyclohexadienone compositions |
| US4707498A (en) * | 1986-01-14 | 1987-11-17 | Merrell Dow Pharmaceuticals Inc. | Fluorinated diaminoalkyne derivatives |
-
1987
- 1987-07-06 IL IL83086A patent/IL83086A/xx unknown
- 1987-07-28 US US07/078,805 patent/US4883805A/en not_active Expired - Fee Related
-
1988
- 1988-03-01 DE DE8888103072T patent/DE3863859D1/de not_active Expired - Lifetime
- 1988-03-01 EP EP88103072A patent/EP0298192B1/en not_active Expired - Lifetime
- 1988-03-01 AT AT88103072T patent/ATE65401T1/de not_active IP Right Cessation
- 1988-03-01 ES ES198888103072T patent/ES2028917T3/es not_active Expired - Lifetime
- 1988-03-07 CA CA000560733A patent/CA1303992C/en not_active Expired - Lifetime
- 1988-03-11 JP JP63056522A patent/JPS6416724A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007515461A (ja) * | 2003-12-23 | 2007-06-14 | ピエール、ファーブル、メディカマン | 非経口投与を目的とするビンフルニンの医薬組成物、その調製方法およびその使用 |
| JP2012102120A (ja) * | 2003-12-23 | 2012-05-31 | Pierre Fabre Medicament | 非経口投与を目的とするビンフルニンの医薬組成物、その調製方法およびその使用 |
| JP2015127300A (ja) * | 2013-12-27 | 2015-07-09 | 富士フイルム株式会社 | 注射液製剤及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2028917T3 (es) | 1992-07-16 |
| IL83086A0 (en) | 1987-12-31 |
| DE3863859D1 (de) | 1991-08-29 |
| US4883805A (en) | 1989-11-28 |
| ATE65401T1 (de) | 1991-08-15 |
| EP0298192B1 (en) | 1991-07-24 |
| JPH0525857B2 (en]) | 1993-04-14 |
| AU604094B2 (en) | 1990-12-06 |
| IL83086A (en) | 1991-03-10 |
| AU1257888A (en) | 1989-01-12 |
| EP0298192A1 (en) | 1989-01-11 |
| CA1303992C (en) | 1992-06-23 |
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